“Hibernoma”: The lipoma of immature adipose tissue

Hibernoma (granular cell lipoma).

Using diffusion weighted MR imaging in a lipomatous chest wall lesion.

Hibemoma is a rare benign soft tissue tumor derived from brown fat.The tumor is also known as "fetal lipoma, lipoma of embryogenic fat and lipoma of immature adipose tissue. Hibemomas are slow-growing, painless soft tissue tumors which do not recur after surgical resection. Preferred locations are brown fat containing sites as thigh, interscapular region, shoulder, axilla, and mediastinum.The t...

Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action.

Aldosterone is a major regulator of salt balance and blood pressure, exerting its effects via the mineralocorticoid receptor (MR). To analyze the regulatory mechanisms controlling tissue-specific expression of the human MR (hMR) in vivo, we have developed transgenic mouse models expressing the SV40 large T antigen (TAg) under the control of each of the two promoters of the hMR gene (P1 or P2). ...

Cellular and molecular features of lipoma tissue: comparison with normal adipose tissue.

BACKGROUND Involvement of adipose-derived stem/progenitor/stromal cells (ASCs) in the development of lipomas has been suggested, but the pathogenesis and pathophysiology of this tumour remain unclear. OBJECTIVES To analyse cellular and transcriptional characteristics of lipoma tissue compared with normal adipose tissue, further to delineate differentiating features. METHODS For lipoma or no...

The Lipid Composition of Hibernoma as Compared with That of Lipoma and of Mouse Brown Fat.

is the morphologic similarity between the tumor and this type of fat : like brown fat, hibernoma is composed, wholly or largely, of multivacuolated fat cells; and both are highly vascular (1). In this study the lipid composition of 2 hibernomas has been compared with that of ordinary lipomas and of mouse brown fat. 1\1ATERIAIS AND METHODS Two patients were operated on for a soft tissue tumor in...